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Mesoblastic Nephroma
A 10-day-old infant presented with hematuria. Multiple CT images show a large heterogeneous mass originating from the lower pole of the right kidney (cortical beak sign noted, pink arrow). The mass extends into the right renal pelvis and causes mild hydronephrosis.
Facts
- Synonyms: mesoblastic nephroma, leiomyomatous hamartoma, mesenchymal hamartoma, renal fibroma, Bolande tumor.
- It is the most common solid renal tumor in the newborn.
- This tumor is believed to arise from metanephric blastema or secondary mesenchyme.
- Patients usually presents with a palpable flank mass.
- Prognosis is excellent with nephrectomy and wide resection
- Large solid intrarenal mass, which typically involves or extends to the renal sinus.
- Hemorrhage, necrosis or cystic portions are uncommon.
References
1. Donnelly LF. Diagnostic imaging pediatrics. Amirsys. Manitoba. 2005.2. Lowe LH, Isuani BH, Heller RM, Stein SM, Johnson JE, Navarro OM, Hernanz-Schulman M. Pediatric renal masses: Wilms tumor and beyond. Pediatric renal masses: Wilms tumor and beyond. Radiographics. 2000; 20:1585-603.
Asbestosis
Facts:
- Only asbestos fibers of 20-150 um in length can reach lower respiratory tract and cause diseases
- Asbestos bodies are formed by macrophages phagocytose the fibers
- Pulmonary fibrosis develops initially in peribronchiolar region and then spreads along peribronchovascular and septal connective tissues, predominantly in the lower lung zones. Cicatricial emphysema and traction bronchiectasis finally ensues.
- Patients usually present late after initial exposure (up to 20 years)
- Difficult to discern on radiograph because pleural involvement often is more conspicuous and may obscure early lung findings
- Dot-like opacities in subpleural lung may be an earliest CT finding of asbestosis
- Curvilinear subpleural lines (as in our case) are lines running parallel to and a few millimeters beneath the pleural surfaces
- Thickening of interlobular septa and intralobular lines
- Traction bronchiectasis and honeycomb lungs (late)
Lange S, Walsh G. Radiology of chest diseases, 3rd ed, 2007.
Upper Extremity Deep Vein Thrombosis
Facts: Upper Extremity Deep Vein Thrombosis
- Secondary form (more common) is believed to be due to intimal injury, venous stasis and hypercoagulability. Primary form (Paget-von Schrotter syndrome) occurs in young adults due to underlying chronic venous compressive abnormality caused by musculoskeletal structures in the costoclavicular space
- Axillosubclavian vein most common location because it is relatively fixed in the thoracic outlet, therefore it is exposed to repeated trauma with arm movement
- Etiology: central venous catheter (CVC), permanent cardiac pacer, mediastinal tumors, radiation, surgery, hypercoagulable states
- Increasingly common. 8% of all DVTs
- Complications: pulmonary embolism, SVC syndrome, postthrombotic venous insufficiency, loss of vascular access
- The most powerful independent predictor of UEDVT = presence of CVC (increases the risk by 7 folds)
- Other risk factors in patients without CVC: young age, lean body weight and inpatient status
- US is the imaging modality of choice
- US shows lack of compressibility, absence of color flow signal and augmentation, visualization of thrombus
- Radiography may show cervical rib, fractured rib or clavicle
References:
1. Joffe HV, Kucher N, Tapson VF, et al. Upper-extremity deep vein thrombosis: a prospective registry of 592 patients. Circulation 2004;110:1605-1611.
2. Greben C and Charles HW. Deep vein thrombosis, upper extremity. In eMedicine, updated Jul 28, 2009.
Lunate Dislocation
Lateral radiograph of the wrist shows a volar dislocation of the lunate (arrow) relative to the position of the radius (R) and capitate (C).
Facts: Lunate Dislocation
- "Spilled teacup" sign (as seen on this lateral radiograph)
- Final stage of perilunate injuries
- Most severe form of perilunate injuries, highest degree of instability
- On lateral view of the wrist, the line drawn along the axis of distal radius, lunate and capitate should be almost straight. In this case, the line is disrupted because lunate is dislocated volarly.
Acute Cholecystitis
Coronal CT images show dilated gallbladder (GB), thickened wall, mucosal hyperenhancement with an obstructing cystic duct stone (arrow) in a 57-year-old man who presents with acute abdominal pain.
Facts: Acute Cholecystitis
- It is a difficult clinical diagnosis. Potential clinical signs that can be helpful to rule in the diagnosis are 1) Murphy sign (positive likelihood ratio = 2.8), 2) RUQ tenderness
- Diagnosis requires a combination of clinical, lab and imaging tests.
- No single clinical finding or lab test has sufficient weight to establish or exclude cholecystitis without further testing (eg, imaging)
- Evaluation of patients with abdominal pain suggestive of cholecystitis continues to rely heavily on the clinical gestalt and diagnostic imaging
- Gallbladder distention*
- Wall thickening*
- Mucosal hyperenhancement
- Pericholecystic fat stranding or fluid
- Gallstones (with sufficient attenuation difference from bile to be visualized)
- CT rim sign (increased enhancement of hepatic parenchyma in the gallbladder fossa)
- CT is less accurate than ultrasound in establishing or excluding cholecystitis. However, CT is better to show complications of cholecystitis such as emphysema, gangrene, perforation, abscess or hemorrhage.
References:1. Trowbridge RL, Rutkowski NK, Shojania KG. Does this patient have acute cholecystitis? JAMA 2003;289:80-86.2. Shakespear JS, Shaaban AM, Rezvani M. CT findings of acute cholecystitis and its complications. AJR 2010;194:1523-1529.3. Fidler J, Paulson EK, Layfield L. CT evaluation of acute cholecystitis: findings and usefulness in diagnosis. AJR 1996;166:1085-1088.
Ovarian Hyperstimulation Syndrome
Ultrasound images show enlarged ovaries with multiple cysts in a woman who had received assisted reproduction procedure. Ascites is also present but not shown on these images.
Facts: Ovarian Hyperstimulation Syndrome (OHSS)
- Complication related to exogenous administration of human chorionic gonadotropin (HCG) for assisted reproduction
- Believed to be due to increased capillary permeability, resulting in fluid shift from intravascular to extravascular compartments
- Broad clinical spectrum, ranging from mild, moderate to severe, but can be life threatening
- Common in mid- to late-luteal phase
- Early signs: abdominal heaviness, tension and pain (due to bilateral ovarian enlargement with multiple cysts)
- Risk factors: young patient (less than 30 years old), underlying polycystic ovaries, high number of follicles and estradiol levels at the time of HCG injection, protocols that utilize GnRH
- Golan classification describes 5 grades of OHSS based on ovarian size, symptoms (abdominal distention, nausea, vomiting, dyspnea), signs (ascites, pleural effusion, hemoconcentration, hypovolemia, oliguria).
- Ultrasound most appropriate imaging to confirm clinical suspicion
- Enlarged ovaries with several cysts
- Ascites, pleural effusion
- Necklace sign (string of ovarian follicles close to the surface of the ovary) may indicate an increased risk of developing this syndrome
Pulmonic Valvular Stenosis
Facts: Pulmonary Valvular Stenosis
- Common congenital heart defects, approximately 10% of all cases
- Classified as subvalvular, valvular and supravalvular stenosis (based on level of obstruction) and as mild, moderate and severe (based on pressure gradient across stenosis). It can occur in branch pulmonary arteries as well
- May occur in isolation (as in our case) or be associated with other complex congenital heart defects
- In severe cases, physical and ECG findings of right axis deviation, right ventricular hypertrophy would be apparent
- Cardiac ultrasound: obstruction at right ventricular outflow tract (RVOT), pulmonary valve (PV), main pulmonary artery, right and left pulmonary arteries, abnormal pulmonary valve annulus, abnormal pressure gradients across RVOT, PV and pulmonary arteries
- Radiography: enlargement of the main pulmonary artery, right ventricular hypertrophy. Radiographic differential diagnoses are pulmonary hypertension, idiopathic dilatation of the pulmonary trunk
References1. Heiden K. Congenital heart defects, simplified. 20092. Castaner E, Gallardo X, Rimola F, et al. Congenital and acquired pulmonary artery anomalies in the adult: radiologic overview. Radiographics 2006;26:349-371.
Giant Bulla Vs. Pneumothorax
Coronal-reformatted CT image confirms the absence of pneumothorax in this case. Several bullae are clearly visualized.
Facts: Bulla, Giant Bulla
- Air-filled space in the lung parenchyma due to destruction of alveolar tissue, distal to terminal bronchiole
- Larger than 2 cm in distended state
- Bullae + emphysema = bullous emphysema (can be congenital or complication of COPD)
- Giant bulla = bulla larger than one third of the hemithorax size and compression of adjacent lung parenchyma
- Important for treatment plan (bulla - no tube thoracostomy; pneumothorax - may need tube thoracostomy if large or symptomatic)
- Differentiation can be difficult on conventional radiography; they can coexist
- Helpful signs for pneumothorax: visible visceral pleural line
- Expiratory chest radiograph may help delineating a visceral pleural line of pneumothorax
- CT scan is the most accurate mean to differentiate the two diagnoses
- "Double wall" sign described in cases with ruptured bulla causing pneumothorax (air outlining both sides of the bulla wall parallel to the chest wall)
Reference:Waseem M, Jones J, Brutus S, et al. Giant bulla mimicking pneumothorax. J Emerg Med 2005;29:155-158.
Intervertebral Disc Calcification
Commonly Found in Elderly
- Found in 80% of elderly cadavers in a large study
- Mostly located in the periphery of the disc (annulus fibrosus), followed by central and diffuse
- Mostly in lower thoracic spine, followed by midthoracic and lumbar spine
- Increase in prevalence with increasing age
- Degenerative disc
- Postoperative, post-traumatic
- Arthritis: ankylosing spondylitis, CPPD, gout
- Metabolic disease: ochronosis, hemochromatosis, hypervitaminosis D
Chanchairujira K, Chung CB, Kim JY, et al. Intervertebral disk calcification of the spine in an elderly population: radiographic prevalence, location, and distribution and correlation with spinal degeneration. Radiology 2004;230:499-503.
Thyroglossal Duct Cyst
Facts:
- Cystic lesion in the midline of the anterior neck near the hyoid bone
- Common, accounted for 70% of all congenital neck mass
- Usually is mobile, midline or slightly off midline
- Can be anywhere along the route from foramen cecum to the lower neck (a path the thyroid gland descends to reach the anterior trachea). But most are below the level of hyoid bone
- Treatment involves removal of the entire duct, part of the hyoid bone and tissue at the base of tongue
- Dermoid cyst
- Liquefied submental or anterior cervical lymph node
Cavernoma
Facts: Cavernoma
- Low-flow vascular anomaly of the brain
- Endothelium-lined blood cavities without muscular or adventitial layers. No brain tissues present between these blood cavities
- May be sporadic, related to prior radiation, or hereditary
- Patients commonly present with seizures due to internal bleeding
- Annual bleeding rate between 0.25 to 0.7% per year
- On follow up, most cavernomas increase in size due to osmotic changes
- 80% are supratentorium, and size between 1-2 cm
- Appearance depends on amount of internal thrombosis, hemorrhage and calcification
- MRI is the modality of choice because it can show various stages of bleeding in the lesion, which is characteristic for cavernoma
- If presents with acute hemorrhage, CT appearance will be similar to intracerebral hemorrhage of other causes. MRI in acute phase may provide a clue to the diagnosis of cavernoma if it shows various stages of bleeding in particular the presence of hemosiderin
- If presents incidentally, cavernoma appears as a hyperdense mass without causing mass effect on CT. If calcified, it will be only partially calcified. On MRI, it shows a complete ring of dark T2 signal due to the presence of hemosiderin (this effect is best seen on GRE T2* sequence)
Kuker W and Forsting M. Cavernomas and Capillary Telangiectasias. In: Baert AL, Knauth M, Sartor K. Intracranial Vascular Malformations and Aneurysms, 2nd revised edition, 2008
Acute Tubular Necrosis
Facts
- May occur immediately or after an initial short period of allograft function
- Related to both donor and recipient factors
- More common in cadaveric kidneys of older donors who sustained warm ischemia time or prolonged hypotensive periods
- Presented with oliguria or anuria early after transplant
- Diagnosis made by exclusion of other factors. Traditional signs (tubular casts, low urine osmolality) not reliable if patients with native partially functioning kidneys
- Treatment: supportive, return to dialysis if anuric (expected recovery of renal function usually within 3 weeks)
- Normal perfusion, variable uptake but no (or delayed) excretion
- Serial scans helpful in determining viability of oliguric kidneys, predicting recovery or deterioration
Resnick MI, Older RA. Diagnosis of Genitourinary Disease, 2nd edition, 1997
Renal Artery Aneurysm
Facts:
- True aneurysms involve all layers of the artery and usually inherited. They can be fusiform or saccular, and are more commonly extraparenchymal in location. Example: fibromuscular dysplasia, Ehlers-Danlos
- False aneurysms involve only some layers of the artery, usually are acquired and saccular. Examples: trauma, iatrogenic, dissection, mycotic
- Intrarenal aneurysms are intraparenchymal, can be either true or false aneurysm. Examples: polyarteritis nodosa, tuberculosis, neurofibromatosis
- Symptomatic: rupture, pain, ischemia, infarction, hypertension
- Diameter more than 2 cm, enlarging or dissection
- Female patient who is pregnant, or contemplating pregnancy
Reference:Lew WK, Weaver FA, Otero CA, et al. Renal artery aneurysm. E-medicine, updated September 17, 2008
Primary Brachial Plexus Tumor
Coronal T1W and T2W MR images of the brachial plexus show a fusiform-shaped mass (large arrows) along the course of the right cervical nerve root (small arrow). The mass demonstrates heterogeneous low T1 and high T2 signal intensity. It has smooth, well circumscribed borders.
Axial T1W post contrast MR image shows heterogeneous enhancement of the mass (arrows) with a central area of non-enhancement.
Facts: Primary Brachial Plexus Tumor
- Rare tumor, most commonly benign with good prognosis after surgical resection
- Clinical presentations: pain, paresthesia, palpable mass
- Common pathology: schwannoma, neurofibroma. Other possibilities: malignant peripheral nerve sheath tumor (MPNST), desmoid, ganglion, epidermoid
- MRI is the study of choice to delineate the margins of tumor from surrounding tissues
- Characteristic feature on any imaging techniques is close relationship with the parent nerve, which helps to exclude other possibilities such as lymphadenopathy, vascular anomalies, etc.
- Low signal on T1, high signal on T2 and heterogeneous enhancement
- MRI cannot differentiate schwannoma from neurofibroma
References:
1. Binder DK, Smith JS, Barbaro NM. Primary brachial plexus tumors: imaging, surgical, and pathological findings in 25 patients. Neurosurg Focus 2004;16.
2. Rettenbacher T, Sogner P, Springer P, et al. Schwannoma of the brachial plexus: cross-sectional imaging diagnosis using CT, sonography, and MR imaging. Eur Radiol 2003;13:1872-1875.
About Case Contributor: Dr. Balachandra is the head of the Department of Radiology at Government General Hospital in Pondicherry, S. India.
Colonic Closed Loop Obstruction
Facts: Closed Loop Obstruction of the Colon
- Colonic obstruction is rarely caused by postoperative adhesion (less than 1%). It is most commonly due to tumor
- CT should be the next imaging work-up to look for a mass. Contrast enema should be omitted due to the risk of perforation
- Closed loop obstruction of the colon usually is due to volvulus, which can be sigmoid (80%), cecal (15%) or involving the transverse colon (5%). Long mesocolon can predispose to malrotated cecum and result in a bascule or volvulus
- Signs of closed loop obstruction on imaging include focally dilated bowel loop with little gas distally and proximally, transition point with a whirl-like appearance at the mesenteric root, mesenteric haziness and free fluid
Reference:Halpert RD. Gastrointestinal imaging case review series, 2nd ed, 2008.
Brenner Tumor of the Ovary
Facts: Complex Ovarian Mass
- Long list of potential causes, encompassing tumor (primary and neoplastic), inflammation and infection in a postmenopausal woman
- Potential tumors: serous and mucinous cystadenoma/cystadenocarcinoma, teratoma, clear cell carcinoma, endometrioid carcinoma, necrotic primary or metastatic tumors
- Most of these (if we think it is neoplasm) would need to be diagnosed histologically because imaging findings are nonspecific and malignancy cannot be excluded
- Uncommon ovarian neoplasm, usually incidentally found
- Women in 5th to 7th decade of life
- Predominantly solid, but can be complex with cystic components when associated with serous and mucinous cystadenomas (seen in up to 30% of cases)
- Can be benign, borderline or malignant
Reference:
Green GE, Mortele KJ, Glickman JN, Benson CB. Brenner tumors of the ovary sonographic and computed tomographic imaging features. J Ultrasound Med 2006;25:1245-1251.
Anatomic Position of Heart Valves
PA and lateral chest radiographs demonstrate anatomic position of three heart valves, A = aortic, M = mitral and T = tricuspid, in a patient with rheumatic valve disease. Note that the tricuspid prosthesis is an annuloplasty.
Facts
- The three heart valves (aortic, mitral and tricuspid) commonly overlap each other on frontal radiograph. Correct radiographic identification can be difficult.
- To differentiate the mitral from aortic valve on lateral view, one draws a line from the junction of the sternum and diaphragm to the carina. This line normally intersects aortic valve*. The valve below the line is mitral valve. The tricuspid valve is the one to the mitral valve.
- Without a lateral view, the best criterion for use in differentiating between aortic and mitral prostheses is the direction of flow (discernable in Starr-Edwards and most Bjork-Shiley prostheses). Orifice (en face or in profile) and orientation (vertical or horizontal) of prosthesis are less reliable.
Our patient's mitral and aortic prostheses are disc type, so their direction of flow was not discernable.
Reference:1. Gross BH, Shirazi KK, Slater AD. Differentiation of aortic and mitral valve prostheses based on postoperative frontal chest radiographs. Radiology 1983;149:389-391.2. Miller SW, Boxt LM, Abbara S. Cardiac Imaging the Requisites, 3rd edition, 2009.
Scimitar Syndrome
Fig. 1: Chest radiograph of an asymptomatic young woman shows small right lung volume with cardiomediastinal shift toward the right side, small right hilum and a characteristic scimitar-shaped structure in the right lower lobe (arrow).
Figs 2&3: Contrast-enhanced CT images (maximal intensity projection, and 3D volumetric images) show an anomalous right lower lobe pulmonary vein (arrows) descending vertically, draining the right lower lobe and entering the IVC.
Facts: Scimitar Syndrome
- Also known as venolobar syndrome, hypogenetic lung syndrome
- Associations: congenital heart disease 25% (usually atrial septal defect)
- Symptoms: usually asymptomatic. Patients may have dyspnea if there is a large left to right shunt
- Small right lung
- Diminutive right hilum
- Dextroposition of the heart
- Characteristic scimitar vein draining below the diaphragm
About Guest Author: Dr. Santip Srisuwan is a radiologist at Samitivej Hospital, Bangkok, Thailand.
Ankylosing Spondylitis (AS)
Facts: AS
- Prototype of seronegative spondyloarthropathies (SNSA), which is a group of disorders of chronic inflammation of sacroiliac joints and spine
- Frequency: about 0.1% - 6% across different population (most likely toward the lower end)
- Genetic risk factor = human leukocyte antigen (HLA)-B27
- Principal bone/joint abnormalities = sacroilitis, synovitis and enthesitis
- Imaging findings are incorporated into the modified New York criteria for ankylosing spondylitis, as one of the four criteria.
- Sacroilitis: pseudowidening, sclerosis, erosions and later ankylosis
- Grading of sacroilitis on radiographs can be viewed here (link to Google Document provided by Schering-Plough Ply)
ReferenceKippel JH. Primer on the rheumatic diseases, 13rd ed, 2008.
Peritonsillar Abscess
Facts: Peritonsillar Infection
- Peritonsillar space is a space between anterior and posterior tonsillar pillar, deep to the tonsillar capsule and below the superior pharyngeal constrictor muscle
- Infection of this space usually arises from tonsillitis or pharyngitis, which can lead to peritonsillar cellulitis or abscess
- Differentiation of cellulitis from abscess has a clinical value, since cellulitis is treated medically but abscess usually requires surgical drainage
- Clinical distinction of the two can be difficult; imaging such as contrast-enhanced CT or ultrasound have been utilized for this purpose
- On CT, abscess appears as a cystic/multilocular low density collection with enhancing rim, with or without presence of gas at the center. Cellulitis appears as homogeneous soft tissue swelling with obliteration of fat planes.